Capsaicin and Atherosclerosis: Health Benefits and Resources

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What is Capsaicin

Capsaicin is a chemical that is found in common places around the house, such as in different foods or garden pesticides. It is primarily found in different types of peppers, such as chili or cayenne peppers. Capsaicin is the component that gives peppers the hot and spicy taste to them, and as a result, one of the reasons people feel pain in their mouths upon eating them.

Capsaicin Chemical Facts

Capsaicin CAS number: 404-86-4
Capsaicin PubChem: 1548943
Capsaicin ChemSpider: 1265957
Capsaicin UNII: S07O44R1ZM
Capsaicin EC number: 206-969-8
Capsaicin ChEMBL: CHEMBL294199
Capsaicin ATC code: M02AB01
Capsaicin Molecular formula: C18H27NO3
Capsaicin Molar mass: 305.41 g/mol
Capsaicin Melting point: 62–65 °C
Capsaicin Boiling point: 210–220 °C @ 0.01 Torr

Using Capsaicin to Treat Medical Conditions and Atherosclerosis

But the medical community has found several other uses for this chemical, aside from its usual role in spicing up our favorite dishes. Capsaicin can be administered in a variety of different forms, including powders or creams, in addition to being served in raw foods.

One of the medical ailments that capsaicin is used for treating is atherosclerosis, or the clotting and hardening of the arteries. This condition does not allow blood to properly circulate in the body, and is considered a serious medical condition. It is considered a stimulant because of the way the body reacts to the pain from capsaicin. For example, when applied as a cream to an area that is feeling pain, it stimulates a physiological response. Similarly, doctors believe that it can also assist in stimulating the entire cardiovascular system. As a result of this stimulation, it may have the ability to reduce cholesterol levels, and as a result, also help aid in the prevention of atherosclerosis, helping to prevent heart attacks or strokes.

That being said, the way in which capsaicin may help a person living with an ailment like atherosclerosis is not as simple as comparing it to the sensation experienced in the mouth when eaten. According to a group of Australian scientists at the University of Tasmania, the key is that capsaicin may prevent the oxidation of low-density lipoprotein, or LDL. LDL is often referred to as the “bad” cholesterol in the body. High levels of LDLs can contribute to atherosclerosis, as the LDLs can lead to oxidation, and eventually to the hardening of the arteries. As they harden, the arteries become stiff and allow less blood to pass through them. This is a result of the large deposits of plaque that is formed by LDLs. A group of scientists shows that capsacinoids, a derivative did reduce the amount of oxidation of LDLs.

Side Effects of Capsaicin

While there are many ways that capsaicin may benefit those seeking treatment of atherosclerosis, it is also important to note some of the side effects when the chemical is taken into the body. As with eating an abundance of spicy foods, irritation of the stomach lining or esophagus may occur, inducing indigestion, nausea, or diarrhea. This can usually be avoided by introducing spicy foods slowly. If taken in raw form, such as directly from a pepper, it may be best to remove some of the seeds, effectively reducing the strength of the capsaicin.

Additionally, as with most of the dietary supplements and vitamins available in the United States, capsaicin is not regulated by the Food and Drug Administration (FDA). As always, it is important to discuss any additional supplements with a primary care doctor or other medical professional prior to consumption. While experts working in medical field consider capsaicin to be safe, the lack of regulatory standards should be noted prior to use.

More Health Benefits of Capsaicin

1. Fight Cancer
A study published in Cancer Research found that capsaicin caused cancer cells to commit suicide.

2. Provide Pain Relief
A topical form of capsaicin is a recognized treatment for osteoarthritis pain, and may also help alleviate pain from diabetic neuropathy.

3. Prevent Sinusitis and Relieve Congestion
Because it is so hot, it also helps to stimulate secretions that help clear mucus from your nose, thereby relieving nasal congestion.

4. Fight Inflammation
It works by inhibiting Substance P, which is associated with inflammatory processes.

5. Soothe Intestinal Diseases
A Duke University study found that capsaicin may lead to a cure for inflammatory bowel disease (IBD).

6. Burn Fat and Lose Weight
Capsaicin is a thermogenic agent, which means it increases metabolic activity. This, in turn, helps to burn calories and fat.

7. Protect Your Heart
Capsaicin may help to protect the heart by reducing cholesterol, triglycerides and platelet aggregation.

Resources About Capsaicin

University of Maryland Further Information: Using cayenne pepper for capsaicin health benefits

UC – San Diego: An overview of capsaicin and its health benefits

Journal of Agriculture and Food Chemistry: More information about capsaicin and lipids

Resource by AnnaBelle

Annalise Kaylor is a freelance writer, editor, and consultant specializing in search engine optimized content for the web. As a writer, her work has appeared across the United States in print ads for Whirlpool, Maytag, Home Depot, and Lowe's, among others. As a consultant, she has worked primarily in the education sector, helping universities increase their web visibility and construct and implement social media strategy. Annalise is an avid reader, knitter, organic gardener and baker, as well as the author of the popular baking blog, Knead To Be Loaved. Annalise enjoys fly fishing, camping, and hiking.

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